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The Diagnostic and Statistical Manual, Fourth Edition (DSM- IV) defines depression by the presence of at least one of two core symptoms: anhedonia; a decreased ability to experience pleasures, and depressive mood; lasting minimally 2 weeks [6, 7]. Since anhedonia, on the one hand, is a cardinal phenomenon of depressive disorders, and on the other, can be evoked in rodents, the hedonic deficit might be considered as a primary feature to be addressed in pre- clinical models of depression. Coping and cognitive deficits, low exploratory motivation, circadian and sleep disturbances, aggressive and anxiety traits, decreased sexual and increased submissive behaviour, social avoidance, deterioration of the coat state and other changes, which can be evoked in animals, with some considerations [8] are regarded as parallels of subsidiary depressive symptoms [9, 1. The aim of this review is to analyze the major methodological drawbacks in mouse models of depression with a focus on its principal feature, anhedonia, in a chronic stress paradigm, and to share with the reader several procedural modifications resulting from our own experiences with a chronic stress model in C5. \ USBclarifyFull.f with MD5.f and usb.ids included inline just for fun V1.0 Howerd Oakford www.inventio.co.uk \ Displays when a USB device is connected and. BL/6. N mice. We believe that the changes to methodology proposed here provide important advances in modelling the neurobiological basis of depression in rodents and that their implication can help develop more effective therapeutic strategies. Challenges in modelling depression and anhedonia using chronic stress paradigms. The chronic stress paradigm is considered to have a greater aetiological relevance and face validity in mimicking depression than other animal models, and therefore has become one of the most broadly used pre- clinical paradigms of this disorder [1. The first experiments using this model were undertaken by Katz and colleagues in rats, and involved rotating stressors applied over 2. These procedures were later modified by Willner resulting in higher length of experiment and lower severity of stressor [1. These experiments resulted in a decreased preference for, and intake of palatable solutions such as sucrose or saccharine. This was defined as stress- induced anhedonia. This anhedonic state was accompanied by an increase in the thresholds required for intracranial self- stimulation and was reversed by anti- depressants, but not by neuroleptics or anxiolytics [1. By now, a number of variants of chronic stress procedures had been proposed in both rats and mice and had been shown to evoke, in addition to anhedonia, the subsidiary depressive- like features mentioned above [1. Regrettably, a number of studies revealed inconsistencies in the induction of hedonic deficit in chronic stress models in both rats and mice [3. For example, in one study, Wistar and PVG hooded rats were subjected to chronic mild stress; stressed animals of both lines showed "unreliable" decreases in sucrose intake, which were "inconsistent" over time. None of stressed animals showed a decrease in the intracranial self- stimulation, evaluated by 5. Problems with reproducibility could also be due partly to the limited accuracy of the sucrose test, which, in its current state, does not have sufficient resolution to discriminate between anhedonic and non- anhedonic individuals within a stressed population [3. In addition, some of multi- disciplinary studies, using anhedonic chronic stress models of depression, have resulted in abstruse and contradictory outcomes, and failed to define a consistent molecular, neuroanatomical and physiological phenotype in either rats or mice. Data on their locomotion, anxiety, exploration, and other behaviours often demonstrated paradoxical and conflicting behavioural changes; many of them showed discrepancies between the behavioural phenotype of chronically stressed animals and human symptoms of depression. Together, controversies with reproducibility of stress- induced anhedonia, defined by sucrose preference data and identification of biological correlates of depression greatly limit the value of this method to model pre- clinical depression [4. Apart from methodological problems, application of the chronic stress approach has encountered some conceptual drawbacks. The most obvious is that in previously proposed models, all effects observed in groups of chronically stressed animals with signs of a decreased sensitivity to reward, are attributed to an hedonic deficit. It is important to note that stress alone can evoke a number of physiological alterations, which are not associated with a depressive- like behavior and anhedonia. With the originally proposed models and their analogues it was not possible to correlate findings obtained in chronically stressed animals with anhedonia, thus, specific biological correlates of hedonic deficit could not be addressed. Studies with our new model of stress- induced anhedonia suggest that unresolved methodological difficulties in measuring behaviour in chronically stressed animals may be the origin of the above problems. Here, we present data obtained across several experiments, which reveal the major sources of behavioural artifacts in chronic stress mouse models of depression. These data enable us to propose several changes to the accepted methodology which are validated by both behavioural and molecular correlates of anhedonia. Anhedonia is exhibited by a subgroup of animals in chronic stress paradigms. Numerous findings show a remarkable inter- individual variability in animals' responses to stress [9, 1. Using a principle of the isolation of responders and non- responders, we have established a mouse model of stress- induced anhedonia with an internal control for the effects of stress alone [4. A four week chronic stress paradigm, comprised of exposing male 3- months- old C5. BL6. N mice to tail suspension and restraint stress in different procedural variants resulted in a decrease of preference to 1% sucrose solution by ≤ 6. Figure 1]. It was shown that sucrose preference is similar in control, non- anhedonic and anhedonic mice before the onset of stress. At the end of the stress induction period sucrose preference and intake markedly decrease and are replaced by an increase in water consumption. Figure 1. Chronic stress results in decreased sucrose preference in a subgroup of mice. After initial increase in sucrose preference on the 3rd week of stress, by the termination of a 4- week stress, a cohort of mice display a prominent decrease in sucrose preference. Mice subjected to chronic stress were split into anhedonic and non- anhedonic subgroups according to the criterion of 6. Reproduction of this material is permitted by Macmillan Publishers Ltd. Recent studies in chronically stressed mice and rats have shown similar partial depressive- like outcomes ([2. Table 1). Resilience or susceptibility to stress- induced anhedonia and/or other physiological parallels of depressive- like state in newly developed models was found to correlate with distinct regulation of mesolimbic dopamine circuits, excitability of dopamine neurons of ventral tegmental area [2. Y, transcription and factors markers, immediate early genes, a dysfunction in the GABAergic system and AMPA- mediated transmission [2. Table 1. Partial depressive- like outcomes in chronic stress models of depression. The inter- individual variability in susceptibility or resilience to stress- induced decreases in sucrose preference observed in these, and our, paradigms suggest that this phenomenon is typical, even for inbred lines of animals [2. A variety of potential mechanisms may underlie this phenomenon: 1) pre- natal and early environmental factors [6. DNA and chromatin modifications, histone acetylation and methylation [6. DNA replicates [6. 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![]() ![]() The Percussive Maintenance trope as used in popular culture. Also known as "Technical Tap", "Ape Mechanics," "Fonzarelli Fix", "Spike Spiegel School Of. ![]() [15 PDF + 8 MP3 + 3 MIDI]. "For 17 years we provide a free and legal service for free sheet music. If you use and like Free-scores.com, thank you to consider. "Spirit in the Sky" is a song written and originally recorded by Norman Greenbaum and released in late 1969. The single became a gold record, selling two million. Free sheet music RECORDERPage 1/2', WIDTH, 4. DELAY,0, OFFSETX, 2. OFFSETY, - 2. 00, BALLOON, false, BORDERWIDTH, 1, PADDING, 3)"; on. "For 17 years we provide a free and legal service for free sheet music. If you use and like Free-scores.com, thank you to consider support donation.Mouse. Out="Un. Tip()"> •Page 2/2', WIDTH, 4. DELAY,0, OFFSETX, 2. OFFSETY, - 2. 00, BALLOON, false, BORDERWIDTH, 1, PADDING, 3)"; on. Mouse. Out="Un. Tip()" class=gj. Spirit in the Sky - Wikipedia. For a deity whose portfolio includes or is limited to the sky, see Spirit of the sky."Spirit in the Sky" is a song written and originally recorded[4] by Norman Greenbaum and released in late 1. The single became a gold record, selling two million copies from 1. US Billboard. Hot 1. April 1. 8, 1. 97. Top 1. 00. Billboard ranked the record the No. It also climbed to number one on the UK, Australian and Canadian charts in 1. Rolling Stone ranked "Spirit in the Sky" No. Greatest Songs of All Time. The song was featured on the 1. Cover versions by Doctor and the Medics and Gareth Gates have also made the number 1 spot in the UK. Original version by Norman Greenbaum[edit]Greenbaum had previously been a member of psychedelicjug band. Dr. West's Medicine Show and Junk Band. When they split up he won a solo contract with producer Erik Jacobsen, who had previously worked successfully with The Lovin' Spoonful. He was inspired to write the song after watching Porter Wagoner on TV singing a gospel song. Greenbaum later said: "I thought, 'Yeah, I could do that,' knowing nothing about gospel music, so I sat down and wrote my own gospel song. It came easy. I wrote the words in 1. Spirit in the Sky" contains lyrics about the afterlife, making several references to Jesus, although Greenbaum is Jewish. In a VH1 episode about famous one- hit wonders, Alice Cooper said that he was surprised to hear someone with a Jewish- sounding last name performing a song that seemed to be about Jesus). Greenbaum recorded his first solo album with Jacobsen for Reprise Records. The song's arrangement came together in the studio in San Francisco where lead guitarist Russell Da. Shiell, bass player Doug Killmer from the band Crowfoot and drummer Norman Mayell worked with Greenbaum. According to one source[4] and to Da. Shiell, Greenbaum used a Fender Telecaster with a fuzz box built into the body to generate the song's characteristic guitar sound. Moreover, Da. Shiell[6] explained how he created the song's distinctive "beeping" fills: "I actually played the lead guitar parts on Spirit, using a 6. SG Les Paul, a 6. Marshall Plexi 1. Marshall. Regarding the 'beep beeps' as I call them, when the producer asked me to play some fills in between the verses, as a joke I said how about something spacey like this and I did the pickup switch/string bending thing. I saw him stand up in the control booth and he said "that's it! There was no slide involved, just my fingers, and I used the bridge humbucker and the pickup switch). The fuzz part is Norman with a built- in overdrive circuit built into his Tele pickguard.""I've been asked a lot over the years how I did the 'beep beep' guitar parts on Spirit, so for any guitar players out there who would like to learn how, try the following: Using a 2- pickup Gibson, set the neck pickup volume to zero, bridge pickup volume to max, with the pickup switch in the middle position (with Gibson wiring this gives you silence in the middle position). Do a string bend, picking the B & E strings together with one hit, just ahead of the beat, then use the pickup switch to kick in the bridge pickup in triplets (6 per bar) as you let the B string bend down two frets.""I mainly used two positions on Spirit, which is in the key of A. For the low position, fret a stationary C note (8th fret) on the E string while bending the B string up to an A note for your starting- position, then pick the two strings together once while the guitar is silent and work the pickup switch as you let the A note bend downwards to a G. For the high position, do the same thing at the 1. G note on the E string while bending down from E to D on the B string.""I must give credit to Jimi Hendrix as my inspiration for this technique (as well as for the double- string riffs I did at the beginning of the Spirit solo tail section). I saw him perform live in a small club in Madison, Wisconsin and loved the way he used his Strat pickup switch to create staccato feedback on songs like Voodoo Child. The difference is, on a Gibson you can start from silence and create the on/off effect, which worked well with the downward string bending thing I did on Spirit."The resulting sound was an innovative and compelling combination of gospel and psychedelic rock music, with loud drums, distorted electric guitar, clapping hands, and tambourines. The production team brought in the Stovall Sisters, an Oakland- based gospel trio, to sing backing vocals. Because of its unusual lyrics and style, the record company was initially reluctant to issue it, but was finally released as a single after two other singles from the album had poor sales. Spirit in the Sky" became a worldwide hit, and was at the time the best- selling single ever for the Reprise label.[citation needed]There is a music video with Greenbaum singing the song.[7]Of the song, Greenbaum observed: "It sounds as fresh today as when it was recorded. I’ve gotten letters from funeral directors telling me that it's their second- most- requested song to play at memorial services, next to 'Danny Boy'."[8]Cultural impact[edit]During John Lennon's scathing 1. Rolling Stone "Beatles break- up" interview with Jann S. Wenner, while highly critical of the recent work of many of his peers, including Bob Dylan and ex- band mate Paul Mc. Cartney, Lennon professed to liking the then- current radio single, "Spirit in the Sky", stating that he "always liked simple rock and nothing else".[9]The song has been featured in several films, television series, documentaries and video games including Rock Band 2, This is the End, Wayne's World 2, Miami Blues, Brooklyn Nine- Nine, The Longest Yard, Suicide Squad, Life,[1. The Founder, Remember the Titans, House, Contact, Supernatural, Michael[1. The Blacklist: Redemption, Shameless, in credits for the 2. Life and it also is heard playing quietly in the first scene of the movie A Simple Plan.[1. Spirit in the Sky" was ranked No. VH1's 1. 00 Greatest One- hit Wonders. It was included on the list of songs deemed "questionable" by Clear Channel following the September 1. The song is used to introduce the starting lineup of the Los Angeles Angels of Anaheim for home games at Angel Stadium. In the Ron Howard movie Apollo 1. Fred Haise character opened the TV broadcast to Earth from the Odyssey Command Module with "Spirit in the Sky" instead of the planned theme from 2. A Space Odyssey. The song appears in the second trailer for Guardians of the Galaxy,[1. The song appears on the feature film Suicide Squad on the scene when Taskforce X travels to midway city on a helicopter, but is not included in the soundtrack album of the film. Greenbaum's version is played, in heavily edited form, in the space film LIFE (2. Greenbaum's version of the song is also heard in: Chart performance[edit]Cover versions and samples[edit]Elton John covered "Spirit in the Sky" in 1. A version by Dorothy Combs Morrison reached #4. Canada in November 1. Bauhaus covered "Spirit In the Sky" on their 1. Sanity Assassin".[3. In 1. 98. 6 the group Doctor and the Medics reached No. UK singles chart with their version of the song, while the same year punk band Fuzzbox released their own less successful version. In 1. 99. 1, The Kentucky Headhunters covered "Spirit In the Sky" on their album, Electric Barnyard.[3. The song was covered by DC Talk for Jesus: Music from & Inspired by the Epic Mini Seriessoundtrack and was released as a B side with Le. Ann Rimes' song "I Need You".[3. Howard Stern and his in- studio band The Losers performed the song in 2. Battle of the Bands with actor Corey Feldman's band Truth Movement. A humorous version of the song recorded to raise money for the charity Comic Relief by The Kumars with Gareth Gates also reached No. UK singles chart. Christian band Stellar Kart covered the song on their 2. Everything Is Different Now.[3. Goldfrapp sampled the song for their single "Ooh La La".[3. Doctor & the Medics version[edit]Gareth Gates (with the Kumars) version[edit]"Spirit in the Sky" served as the first single from Pop Idol runner- up Gareth Gates' second studio album, Go Your Own Way. The single was released on March 1. Comic Relief charity single for 2. The song features guest vocals from The Kumars. The song peaked at number one on the UK Singles Chart, becoming Gates' fourth number one single. Track listing[edit]UK CD1"Spirit in the Sky" – 3: 2. Dance Again" – 4: 0. Spirit in the Sky" (Gareth Only Version) – 3: 2. Spirit in the Sky" (Video) – 4: 0. Pavtube Video Converter for Mac. Q: I purchased and tried installing your software on a Mac pro with leopard 1. Install Failed - The Installer could install some files in "/Applications". Contact the software manufacturer for assistance. A: Pavtube has been updated to support the coming Mac Mountain Lion system. This new pkg file may have problem to install on Mac OSX 1. The Mac Mini VMware ESXi 5 Server – Part 2 (Installation) January 10th, 2012 // 10:16 pm @ Paraguin. This is Part 2 of the Mac Mini VMware.If you have this problem pls download the special installation file for Mac OSX 1. Further question, you can contact macsupport@pavtube. Q: I just purchased Pavtube (so I have the latest version). I am using it to convert my camera video files into a format that is compatible with Final Cut Pro for video editing. But none of the FCP formats seem to work. The conversion takes place but I only get an audio file and no video. Final Cut Pro (nor any other program) cannot open these files. Converting the video files to other formats i. Quicktime HD, works perfectly well, but none of the "Final Cut Pro" presets do. Is there something I'm missing or is there a bug in the program? A: To convert correctly with Final Cut Pro output formats it is required your computer must be installed with FCP, otherwise there will only be audio without video in the generated file. Q: Trying to convert MXF files from Canon XF3. There are 1 MXF files without source audio files. Please put the relative source audio files to the same directory with the MXF videos, or to the relative Audio folder, and import the MXF video files again. The mentioned MXF video files: If the converted files are abnormalities of voice sound , please contact the customer support."There are no more files that I can add and all files are in teh same directory with mxf same results with no sound form hard disk after import through canon xf utility or straight from CF card. A: This problem has been fixed in latest release on March 1. If not, pls download the update from your pavtube account or contact macsupport@pavtube. Q: My videos were recorded by my HD camcorder, there are many stripes and noises on the picture after conversion, why should this happen? A: Some footages are taken under interlacing mode, and this lead to stripes and lines on the screen. To eliminate the lines, you may follow ‘Edit’ menu- > ‘Effect’ tab and check ‘Deinterlacing’ box before conversion. As to the noise, when you apply the special effect mode “Simple Gauss Blur” from the drop- down list, the noise will be reduced greatly. Q: What are the differences between the trial version and the retail version? It’s that time of year when Intel, the largest maker of laptop and desktop processors in the world, announces the guts of your future PC. These CPUs are always a. MAC OS X OSX Troubleshooting 10.9 Mavericks 10.8 Lion 10.7 Snow Leopard 10.6 10.5 Tiger 10.4 Panther 10.3 Jaguar 10.2 Free Tutorial White Paper Basic Apple. ![]() Updates. Apple refreshed the entire MacBook Pro line on October 24, 2006 to include Intel Core 2 Duo processors. Memory capacity was doubled for each model, to 1 GB. A: A trail version converts videos with watermark (the logo of Pavtube) on the screen and asks if you would like to purchase at each run while a retail version allows you to use freely without putting on watermark. As a customer of Pavtube, you will be reminded to update the software whenever a new version is released. The update is free of charge for lifetime. Besides, your emails will be attended at the first time, your advice and requirements will be much valued when we upgrade the software. Q: How to combine multiple video clips into one file? A: Select the items you want to combine together and check the box of ‘Merge into one file’ before converting the videos. Q: My widescreen movies (1. I don't want the video to be stretched and made taller. What can I do? A: Simply click ‘Settings’ button and set the Video Size to 1. Q: How can I set the output file name? A: Please find the column named ‘Destination File’ on file list. Double click the output name and then you can type in desired output file name. Q: I’d like to eliminate black bars (edges) from the movie, what should I do? A: Click ‘Edit’ button to enter into the edit panel and switch to the Crop tab, then just drag the dashed frame on the video screen of the original preview window to cut off the unwanted parts to get the right aspect ratio you need. Q: How do I install and register the software? A: Please find more details at Install and register Mac products. Q: I am unable to download the program properly. What can I do? A: Please check whether your computer has been infected. Then check your IE settings. Please click "Internet option.." under "Tools", and then select the "General" Page, just click "Delete file..", and it will be OK. Can I change the output file name? Yes. Please find the column named "Destination File" on file list. Click the particular output name under the "Destination File" column, and then you can specify the output file name. Muzzle Automatically Disables OS X Notifications When You Screen- Share. When you’re sharing your screen for a business or school presentation, you don’t want any notifications popping up, like a sext, a calendar notification for your therapist appointment, or a Slack DM about the problem client you’re currently presenting to. You could hit “Do Not Disturb,” but what if you forget? While Windows 1. 0 has a built- in option to turn notifications off during screen- shares, OS X doesn’t. The free app Muzzle fixes that. Muzzle mutes notifications while you screen- share with Slack, Google Hangouts, join. Skype. It sits quietly in your menu bar and uses zero memory when you’re not screen sharing, says its developer Bryan D K Jones. As depicted above, the app’s download page displays an endless array of humiliating notifications you might want to avoid. If Jones’s fake notifications are funny to you, keep an eye out for the prank app he says he’s working on, which will deliver them to your actual desktop. By the way, the app’s tiny interface includes a goofy button labeled “Mach Override.” Go ahead and push it; it doesn’t actually do anything. Which seems like a foolhardy joke to make in an anti- embarrassment app, so we’re warning you here. India New projects,business opportunities in India,business in India,new business opportunities,investment opportunities in India,sales leads,Business leads/. Home › Articles › Digest Of Important Judgements On Transfer Pricing, International Tax And Domestic Tax (Jan To March 2017). ![]() Wipro selected as a strategic partner for Data Center Services by innogy. Frankfurt, Germany & Bangalore, India - September 15th, 2017. Read more. Sophisticated content for financial advisors around investment strategies, industry trends, and advisor education.FREE PAPERS (ORAL)Amlan Kusum Jana*1, Neelanjana Paul. Sujit Sarkhel. 3, Samir Kumar Praharaj. ![]() ![]() Debasish Sanyal. 51. KPC Medical College, Kolkata, India, moc. ICARE Institute of Medical Sciences & Research, Haldia, India, moc. Institute of Psychiatry, Kolkata, India, moc. Kasturba Medical College, Manipal, India, ni. KPC Medical College, Kolkata, India, moc. Keyword: Renal transplantation, psychiatric comorbidity, legal issues. Introduction: Renal transplantation (RT) is an accepted mode of treatment of end stage renal disease (ESRD), providing a favorable outcome both in renal function as well as quality of life. There is a bidirectional interaction between Psychiatry and RT. ESRD itself may cause various behavioral disturbances. Transplantation is a potential source of stress, in the donor due to organ loss, who is also a relative of patient, in most cases. There are psychosocial issues like restrictions in lifestyle after transplantation, cost, and vocational changes. Moreover, use of steroids and other immunosuppresants after RT may directly cause psychiatric comorbidity. Psychiatric comorbidities have been described in other modes of transplantation as well. However, the sheer volume of patients in RT is higher, making it more relevant than others for studies on comorbidities. Psychiatric co- morbidities in renal transplantation in RT can arise out of stress of the procedure, change of lifestyle, introduction of new medications, or from their combinations. Depression and anxiety are the commonest, though psychosis is not rare. Symptoms are often precipitated or worsened by complications of illness e. Quality of life generally improve from pre RT level but worsens with onset of psychiatric illnesses. Treatment of psychiatric disorders in transplantation recipients is a therapeutic challenge. Many psychotropic drugs are unsuitable for use in renal impairment. Changes in pharmacokinetics, with reduced capacity of patients to excrete drugs and their metabolites, has to be considered along with possible interactions of psychotropics with other drugs that he may be receiving. It is also interesting to discuss as to what extent treatment of psychiatric disorders can alter outcome of transplantation. Legal issues: There is controversy in RT about legality of related and unrelated donors, with most states in India disallowing unrelated donors, except West Bengal. Another pertinent issue is cadaveric transplantation, which is being conducted nowadays though not very commonly. Research status and future directions: There is lack of research in psychiatry in this population. There are methodological difficulties in assessing psychiatric co- morbidities, though qualitative and quantitative research is being undertaken in some multi- disciplinary, tertiary hospitals in our country. |
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